Linguists rely on intuitive conceptions of structure when comparing expressions and languages. In an algebraic presentation of a language, some natural notions of similarity can be rigorously defined (e.g. among elements of a language, equivalence w.r.t. isomorphisms of the language; and among languages, equivalence w.r.t. isomorphisms of symmetry groups), but it tums out that slightly more complex and nonstandard notions are needed to capture the kinds of comparisons linguists want to make. This paper identihes some of the important notions of (...) structural similarity, with attention to similarity claims that are prominent in the current linguistic tradition of transformational grammar. @ 2002 Elsevier Science B.V. All rights reserved. (shrink)

Noam Chomsky and other linguists and psychologists have suggested that human linguistic behavior is somehow governed by a mental representation of a transformational grammar. Challenges to this controversial claim have often been met by invoking an explicitly computational perspective: It makes perfect sense to suppose that a grammar could be represented in the memory of a computational device and that this grammar could govern the device's use of a language. This paper urges, however, that the claim that humans are such (...) a device is unsupported and that it seems unlikely that linguists and psychologists really want to claim any such thing. Evidence for the linguists' original claim is drawn from three main sources: the explanation of language comprehension and other linguistic abilities; evidence for formal properties of the rules of the grammar; and the explanation of language acquisition. It is argued in this paper that none of these sources provides support for the view that the grammar governs language processing in something like the way a program governs the operation of a programmed machine. The computational approach, on the contrary, suggests ways in which linguistic abilities can be explained without the attribution of any explicit representation of rules governing linguistic behavior. (shrink)

By formalizing recent syntactic theories for natural languages Stabler shows how their complexity can be handled without guesswork or oversimplification. By formalizing recent syntactic theories for natural languages in the tradition of Chomsky's Barriers, Stabler shows how their complexity can be handled without guesswork or oversimplification. He introduces logical representations of these theories together with special deductive techniques for exploring their consequences that will provide linguists with a valuable tool for deriving and testing theoretical predictions and for experimenting with alternative (...) formulations of grammatical principles. Stabler's novel approach allows results to be deduced with straightforward calculations and provides a systematic framework for tackling the problem of how speakers can infer the properties of an utterance from principles of the grammar. The special treatment of equality, induction principles, and inclusion of a general method for collecting structures from proofs means that sophisticated linguistic arguments can be carried out in detail, giving a rich perspective to issues in linguistic theory and parsing. (shrink)

As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to (...) test vaccines in wild populations of apes: i) protect apes; ii) reduce Ebola transmission from wild animals to humans; and iii) accelerate vaccine development and licensing for humans. Data obtained from studies of vaccines among wild apes and chimpanzees may even be considered sufficient for licensing new vaccines for humans. This strategy will serve to benefit both wild apes and humans. (shrink)

The heme‐containing cytochromes P‐450 are a ubiquitous family of monooxygenase isozymes responsible for the oxidative metabolism of a wide variety of endogenous as well as exogenous compounds. Many of the compounds metabolized by this enzyme system are effectively detoxified and converted to derivatives more easily eliminated from the organism. However, some compounds can be activated to reactive species capable of eliciting a cascade of toxic lesions, including cancer. Since its discovery nearly 30 years ago, the cytochrome P‐450 enzyme system has (...) received a great deal of attention, particularly in the areas of their mechanisms of metabolism, range of substrate specificity, the purification and characterization of the multiple isozymes and, more recently, the regulation of expression of specific forms. This review will discuss current notions concerning the expression of at least one cytochrome P‐450 isozyme and future directions that should lead to a more complete understanding of cytochrome P‐450 gene expression in general, particularly as it impacts upon biochemical pharmacology. (shrink)

Historical studies may become classics for the wrong reasons, as did Henry Thode's Francis of Assisi or Michelet's Joan of Arc, which we now regard as cultural icons in their own right, emblems of specific elements of the cultures of the era in which they were written. We do not, however, read them for the insight they provide into their declared subjects, nor are their conclusions those of current scholarship. Other studies become classics for the right reasons. The year 1999 (...) marks the eightieth anniversary of the publication of Johan Huizinga's Herfsttij der Middeleeuwen: Studie over levens- en gedachtenvormen der veertiende en vijftiende eeuw in Frankrijk en de Nederlanden, “The Autumn [or Harvest, or Waning, or Decline, or Evening] of the Middle Ages: A Study of the Forms of Life and Thought in the Fourteenth and Fifteenth Centuries in France and the Netherlands [or the Low Countries, or the Burgundian Low Countries].”. (shrink)

Saul Kripke has proposed an argument to show that there is a serious problem with many computational accounts of physical systems and with functionalist theories in the philosophy of mind. The problem with computational accounts is roughly that they provide no noncircular way to maintain that any particular function with an infinite domain is realized by any physical system, and functionalism has the similar problem because of the character of the functional systems that are supposed to be realized by organisms. (...) This paper shows that the standard account of what it is for a physical system to compute a function can avoid Kripke's criticisms without being reduced to circularity; a very minor and natural elaboration of the standard account suffices to save both functionalist theories and computational accounts generally. (shrink)

We illustrate a novel conception of linguistic invariant which applies to grammars of different natural languages even though they may use different categories and have difl'erent rules. We illustrate formally how semantically defined notions, such as "is an anaphor" may be invariant in all linguistically motivated grammars, and we show that individual morphemes, such as case markers, may be invariant in grammars that have them in exactly the same sense in which properties, such as "is a Verb Phrase" or relations (...) such as "is a constituent of". (shrink)

While researchers have examined the types of ethical issues that arise in long-term care, few studies have explored long-term care nurses’ experiences of moral distress and fewer still have examined responses to initial moral distress. Using an interpretive description approach, 15 nurses working in long-term care settings within one city in Canada were interviewed about their responses to experiences of initial moral distress, resources or supports they identified as helpful or potentially helpful in dealing with these situations, and factors that (...) hindered nurses in their responses. Using a thematic analysis process, three major themes were identified from the nurses’ experiences: (i) the context of the situation matters; (ii) the value of coming together as a team; and (iii) looking for outside direction. The work of responding to initial moral distress was more fruitful if opportunities existed to discuss conflicts with other team members and if managers supported nurses in moving their concerns forward through meetings or conversations with the team, physician, or family. Access to objective others and opportunities for education about ethics were also identified as important for dealing with value conflicts. (shrink)

Plotinus’ famous treatise against the Gnostics (33), together with contemporary and thematically related treatises on Intelligible Beauty (31), on Number (34), and on Free Will and the Will of the One (39), can be seen as providing the essential components of a Plotinian defense of polytheism against conceptual moves that, while associated for him primarily with Gnostic sectarians overlapping with Platonic philosophical circles, will become typical of monotheism in its era of hegemony. When Plotinus’ Gnostics ‘contract’ divinity into a single (...) God, they not only devalue the cosmos for its multiplicity and diversity, but also multiply intelligible principles unreasonably. This is because they have foreclosed the distinction, which is to become increasingly explicit in the later antique Platonists, between the intelligible and that which is given existentially, the domain belonging to Plotinus’ indeterminate multiplicity of ‘intelligible Gods’, as opposed to the dialectically determinate number of intelligible principles. Plotinus is prescient in recognizing that incipient monotheism threatens to erase the distinction between philosophy and theology, and between both of these and psychology, the final outcome of which can only be solipsism or nihilism. The defense of polytheism is seen in this fashion to be essential to the preservation of the space for philosophical discourse. (shrink)

I argue that we can explain how we acquire knowledge from what a speaker tells us by appealing to facts about the speaker's reasons for telling. That is because (1) among our reasons for telling somebody that P can be the fact that P; and (2) these reasons that are facts can be made manifest to our audiences by our telling them that P.

At Epistles 2.2.87–9 Horace introduces an argument against writing poetry based on the unpleasant mutual admiration required in poetic society with an anecdote about an orator and a jurisconsult: †frater erat Romae† consulti rhetor, ut alter alterius sermone meros audiret honores, Gracchus ut hic illi, foret huic ut Mucius ille.

At Epistles 2.2.87–9 Horace introduces an argument against writing poetry based on the unpleasant mutual admiration required in poetic society with an anecdote about an orator and a jurisconsult: †frater erat Romae† consulti rhetor, ut alter alterius sermone meros audiret honores, Gracchus ut hic illi, foret huic ut Mucius ille.

This essay is a reflection on how ethical violations continue to have an impact across generations within families of vulnerable populations that have experienced significant breaches in biomedical research. The focus is on the surviving family members of the United States Public Health Service Syphilis Study at Tuskegee (USPHS). Emphasis will be on responsible ethical practices in research and the use of an unique approach narrative storytelling to address the needs of family descendents who have been impacted by the USPHS (...) Syphilis Study. (shrink)

Saul Kripke has proposed an argument to show that there is a serious problem with many computational accounts of physical systems and with functionalist theories in the philosophy of mind. The problem with computational accounts is roughly that they provide no noncircular way to maintain that any particular function with an infinite domain is realized by any physical system, and functionalism has the similar problem because of the character of the functional systems that are supposed to be realized by organisms. (...) This paper shows that the standard account of what it is for a physical system to compute a function can avoid Kripke's criticisms without being reduced to circularity; a very minor and natural elaboration of the standard account suffices to save both functionalist theories and computational accounts generally. (shrink)